Article
A Single Nucleotide ADA Genetic Variant Is Associated to Central Inflammation and Clinical Presentation in MS: Implications for Cladribine Treatment.
Genes - 30 Sept 2020
Stampanoni Bassi Mario, Buttari Fabio, Simonelli Ilaria, Gilio Luana, Furlan Roberto, Finardi Annamaria, Marfia Girolama Alessandra, Visconti Andrea, Paolillo Andrea, Storto Marianna, Gambardella Stefano, Ferese Rosangela, Salvetti Marco, Uccelli Antonio, Matarese Giuseppe, Centonze Diego, De Vito Francesca
Abstract excerpt
In multiple sclerosis (MS), activated T and B lymphocytes and microglial cells release various proinflammatory cytokines, promoting neuroinflammation and negatively affecting the course of the disease. The immune response homeostasis is crucially regulated by the activity of the enzyme adenosine deaminase (ADA), as evidenced in patients with genetic ADA deficiency and in those treated with cladribine tablets. We...
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