Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.

doi:10.1016/j.eplepsyres.2020.106471

Article

Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.

Epilepsy research - 1 Nov 2020

Soontornpun Atiwat, Manoyana Natthakarn, Apaijai Nattayaporn, Pinyopornpanish Kanokporn, Pinyopornpanish Kanokwan, Nadsasarn Angkana, Tanprawate Surat, Chattipakorn Nipon, Chattipakorn Siriporn C

Abstract excerpt

OBJECTIVE: The study aims to test the effect of influenza vaccination on phenytoin, CYP2C9, and IFNγ levels in epileptic patients receiving phenytoin monotherapy METHODS: Thirty-one epileptic patients receiving stable-dose phenytoin monotherapy were enrolled onto the study. Serum concentrations of phenytoin, CYP2C9, and IFNγ were compared before and after influenza immunization. The participants were given 0.5 mL...

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Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy.

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