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Article

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans.

Nature communications - 1 Oct 2020

Sha Qian-Qian, Zheng Wei, Wu Yun-Wen, Li Sen, Guo Lei, Zhang Shuoping, Lin Ge, Ou Xiang-Hong, Fan Heng-Yu

Abstract excerpt

Maternal mRNA clearance is an essential process that occurs during maternal-to-zygotic transition (MZT). However, the dynamics, functional importance, and pathological relevance of maternal mRNA decay in human preimplantation embryos have not yet been analyzed. Here we report the zygotic genome activation (ZGA)-dependent and -independent maternal mRNA clearance processes during human MZT and demonstrate that...

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Identifiers

PMID: 33004802
DOI: 10.1038/s41467-020-18680-6
PMCID: PMC7530992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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