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Article

Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood.

International journal of molecular sciences - 29 Sept 2020

Bertrand-Gaday Christelle, Letheule Martine, Blanchet Emilie, Vernus Barbara, Pessemesse Laurence, Bonnet-Garnier Amélie, Bonnieu Anne, Casas François

Abstract excerpt

Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that pyruvate as the only source of carbohydrate in the culture medium of mouse one cell stage embryo influenced the establishment of the...

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Identifiers

PMID: 33003470
DOI: 10.3390/ijms21197203
PMCID: PMC7582979

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