Article
Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring.
Cell reports - 3 Nov 2020
Oelkrug Rebecca, Krause Christin, Herrmann Beate, Resch Julia, Gachkar Sogol, El Gammal Alexander T, Wolter Stefan, Mann Oliver, Oster Henrik, Kirchner Henriette, Mittag Jens
Abstract excerpt
Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal thermogenesis alter the metabolic phenotype already in the next generation. Male offspring of mothers genetically lacking brown adipose tissue (BAT) thermogenesis display increased...
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