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Article

Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation

27 Sept 2020

Abstract excerpt

Growth differentiation factor (GDF) family members have been implicated in the development and maintenance of healthy nucleus pulposus (NP) tissue, making them promising therapeutic candidates for treatment of intervertebral disc (IVD) degeneration and associated back pain. GDF6 has been shown to promote discogenic differentiation of mesenchymal stem cells, but its effect on NP cells remains largely unknown. Our...

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PMID: 32992671
DOI: 10.3390/ijms21197143

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