Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.

doi:10.1016/j.cell.2020.09.009

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Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.

Cell - 29 Oct 2020

Ha Connie W Y, Martin Anthony, Sepich-Poore Gregory D, Shi Baochen, Wang Yizhou, Gouin Kenneth, Humphrey Gregory, Sanders Karenina, Ratnayake Yasiru, Chan Kelvin S L, Hendrick Gustaf, Caldera J R, Arias Christian, Moskowitz Jacob E, Ho Sui Shannan J, Yang Shaohong, Underhill David, Brady Matthew J, Knott Simon, Kaihara Kelly, Steinbaugh Michael J, Li Huiying, McGovern Dermot P B, Knight Rob, Fleshner Phillip, Devkota Suzanne

Abstract excerpt

A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and fibrotic intestine. In the current study, we explore whether microbial translocation in CD serves as a central cue for CrF development. We discovered a subset of mucosal-associated gut bacteria that consistently translocated and...

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PMID: 32991841
DOI: 10.1016/j.cell.2020.09.009
PMCID: PMC7521382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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