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Article

Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast.

The journals of gerontology. Series A, Biological sciences and medical sciences - 18 Jan 2021

Rallis Charalampos, Mülleder Michael, Smith Graeme, Au Yan Zi, Ralser Markus, Bähler Jürg

Abstract excerpt

Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in free, intracellular amino acids during aging. Here, we determine free amino acid levels during chronological aging of nondividing fission yeast cells. We compare wild-type with long-lived mutant cells that lack the Pka1 protein of the protein kinase A signalling...

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Identifiers

PMID: 32991693
DOI: 10.1093/gerona/glaa246
PMCID: PMC7812441

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