Article
Demetylation of the sex-determining region Y gene promoter and incidence of disorder of sex development in cloned dog males.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Apr 2020
Hwang K C, Choi Y K, Jeong Y I, Park K B, Choi E J, Jeong Y W, Hossein M S, Hyun S H, Jeung E-B, Hwang W S
Abstract excerpt
Canine cloning is occasionally accompanied by abnormal sexual development. Some male donor cells produce cloned pups with female external genitalia and complete male gonadal dysgenesis, which is classified as an XY disorder of sex development (XY DSD). In this study, we examine the potential of 5-aza-2'-deoxycytidine (5-aza-dC), a DNA methyltransferase inhibitor, to reduce the phenotypic abnormality XY DSD in...
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