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Article

Distinct novel quinazolinone exhibits selective inhibition in MGC-803 cancer cells by dictating mutant p53 function.

European journal of medicinal chemistry - 5 May 2015

Zhang Guo-Hai, Xue Wen-Bin, An Yun-Feng, Yuan Jing-Mei, Qin Jiang-Ke, Pan Cheng-Xue, Su Gui-Fa

Abstract excerpt

The mutant p53 proteins and their corresponding cellular response can be manipulated by novel quinazolinone derivatives 4-8 (a-i) in p53 mutant cancer cells. Of the two most potent compounds, 4a exhibited promising broad-spectrum anti-cancer effects, whereas 6c showed selective and exclusive inhibition activity in p53 mutant cancer cell lines but low toxicity to wild-type p53 cancer cell A375 and normal lung...

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Source

Identifiers

PMID: 25828929
DOI: 10.1016/j.ejmech.2015.03.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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