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Article

RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2020

Sharma Deepika, Malik Ankit, Balakrishnan Arjun, Malireddi R K Subbarao, Kanneganti Thirumala-Devi

Abstract excerpt

Mutations in MEFV, the gene encoding pyrin in humans, are associated with the autoinflammatory disorder familial Mediterranean fever. Pyrin is an innate sensor that assembles into an inflammasome complex in response to Rho-modifying toxins, including Clostridium difficile toxins A and B. Cell death pathways have been shown to intersect with and modulate inflammasome activation, thereby affecting host defense....

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Identifiers

PMID: 32989095
DOI: 10.4049/jimmunol.2000244
PMCID: PMC9447007

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RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling.PMID 32989095Read ↗

The immunological function of familial Mediterranean fever disease protein PyrinSemantic proximity Read ↗

The pyrin inflammasome and the Yersinia effector interaction.Semantic proximity Read ↗

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.Semantic proximity Read ↗

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.Semantic proximity Read ↗

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.Semantic proximity Read ↗

Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasomeSemantic proximity Read ↗

Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes.Semantic proximity Read ↗

Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome.Semantic proximity Read ↗

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.Semantic proximity Read ↗

Evidence for the involvement of mTOR inhibition and basal autophagy in familial Mediterranean fever phenotype.Semantic proximity Read ↗

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation.Semantic proximity Read ↗

The <i>Yersinia pestis</i> effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunitySemantic proximity Read ↗

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