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Article

Evidence for the involvement of mTOR inhibition and basal autophagy in familial Mediterranean fever phenotype.

Human immunology - 1 Feb 2011

Mitroulis Ioannis, Kourtzelis Ioannis, Kambas Konstantinos, Chrysanthopoulou Akrivi, Ritis Konstantinos

Abstract excerpt

Familial Mediterranean fever (FMF) inflammatory attacks are often triggered by metabolic or physical stress. mTOR signaling and autophagy modulate cellular responses to metabolic danger signals. In this study, we investigated the implication of mTOR inhibition and autophagy in FMF pathophysiology. mTOR inhibition induced MEFV gene expression in polymorphonuclear cells (PMNs) from healthy individuals, whereas it...

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Source

Identifiers

PMID: 21081147
DOI: 10.1016/j.humimm.2010.11.006

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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