Article
Association of Androgens and Gonadotropins with Amnestic Mild Cognitive Impairment and Probable Alzheimer's Disease in Chinese Elderly Men.
Journal of Alzheimer's disease : JAD - 1 Jan 2020
Li Yan, Li Sha, Xu Shunjiang, Yu Hong, Tang Longmei, Liu Xiaoyun, Wang Xuemei, Zhang Yuanyuan, Zhang Kaixia, Mi Shixiong, Chen Meiqin, Cui Huixian
Abstract excerpt
BACKGROUND: Age-related hormone changes play important roles in cognitive decline in older men, and apolipoprotein E ɛ4 (APOEɛ4) is a risk factor for Alzheimer's disease (AD). OBJECTIVE: This study aimed to investigate the interactive role of androgen decline and APOEɛ4 genotype in the pathogenesis of amnestic mild cognitive impairment (aMCI) and AD. METHODS: In total, 576 elderly men over 65 years old from...
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