Article
Protection of chicks from Newcastle disease by combined vaccination with a plasmid DNA and the pre-fusion protein of the virulent genotype VII of Newcastle disease virus.
Vaccine - 27 Oct 2020
Sun Junfeng, Han Zongxi, Zhao Ran, Ai Hui, Chen Linna, Li Le, Liu Shengwang
Abstract excerpt
In this study, four codon optimized plasmids (designated as pCAG-optiF-1, 2, -3, and -4) containing modified F genes from the epidemic and virulent NDV genotype VII strain isolated in China that is expected to express the pre-fusion conformation of the F protein were constructed. The expression of these F variants in chicken-derived cells was detected by an indirect immunofluorescence assay and western blot...
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