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Article

Patient-Specific Drug Screening Using a Human Induced Pluripotent Stem Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Type 2.

Circulation. Arrhythmia and electrophysiology - 1 Jun 2017

Maizels Leonid, Huber Irit, Arbel Gil, Tijsen Anke J, Gepstein Amira, Khoury Asaad, Gepstein Lior

Abstract excerpt

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) results from autosomal recessive CASQ2 mutations, causing abnormal Ca2+-handling and malignant ventricular arrhythmias. We aimed to establish a patient-specific human induced pluripotent stem cell (hiPSC) model of CPVT2 and to use the generated hiPSC-derived cardiomyocytes to gain insights into patient-specific disease mechanism and...

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Identifiers

PMID: 28630169
DOI: 10.1161/CIRCEP.116.004725

Genes

CASQ2

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