Article
Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease.
Journal of virology - 1 Feb 2011
Emonet Sebastien F, Seregin Alexey V, Yun Nadezhda E, Poussard Allison L, Walker Aida G, de la Torre Juan C, Paessler Slobodan
Abstract excerpt
The New World arenavirus Junin virus (JUNV) is the causative agent of Argentine hemorrhagic fever (AHF), which is associated with high morbidity and significant mortality. Several pathogenic strains of JUNV have been documented, and a highly attenuated vaccine strain (Candid #1) was generated and used to vaccinate the human population at risk. The identification and functional characterization of viral genetic...
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