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Bivalent Junin & Machupo experimental vaccine based on alphavirus RNA replicon vector

25 Feb 2020

Abstract excerpt

Junin (JUNV) and Machupo (MACV), two mammalian arenaviruses placed on the 2018 WHO watch list, are prevalent in South America causing Argentine and Bolivian hemorrhagic fevers (AHF and BHF), respectively. The live attenuated JUNV vaccine, Candid #1, significantly reduced the incidence of AHF. Vaccination induces neutralizing antibody (nAb) responses which effectively target GP1 (the viral attachment glycoprotein)...

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PMID: 32111526
DOI: 10.1016/j.vaccine.2020.02.053

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