Article
Soluble HLA-G and HLA-G Bearing Extracellular Vesicles Affect ILT-2 Positive and ILT-2 Negative CD8 T Cells Complementary.
Frontiers in immunology - 1 Jan 2020
Schwich Esther, Hò Gia-Gia T, LeMaoult Joel, Bade-Döding Christina, Carosella Edgardo D, Horn Peter A, Rebmann Vera
Abstract excerpt
Tumor immune escape is associated with both, the expression of immune checkpoint molecules on peripheral immune cells and soluble forms of the human leukocyte antigen-G (HLA-G) in the blood, which are consequently discussed as clinical biomarker for disease status and outcome of cancer patients. HLA-G preferentially interacts with the inhibitory receptor immunoglobulin-like transcript (ILT) receptor-2 in the...
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