Article
Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells.
Frontiers in immunology - 1 Jan 2020
Lehmann Nadine, Paret Claudia, El Malki Khalifa, Russo Alexandra, Neu Marie Astrid, Wingerter Arthur, Seidmann Larissa, Foersch Sebastian, Ziegler Nicole, Roth Lea, Backes Nora, Sandhoff Roger, Faber Joerg
Abstract excerpt
Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer. Tumor cells can be recognized and killed by conventional and unconventional T cells. Unconventional T cells are able to recognize lipid antigens presented via CD1 molecules independently from major...
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