Article
Immunohistochemistry and Mutation Analysis of SDHx Genes in Carotid Paragangliomas.
International journal of molecular sciences - 22 Sept 2020
Snezhkina Anastasiya V, Kalinin Dmitry V, Pavlov Vladislav S, Lukyanova Elena N, Golovyuk Alexander L, Fedorova Maria S, Pudova Elena A, Savvateeva Maria V, Stepanov Oleg A, Poloznikov Andrey A, Demidova Tatiana B, Melnikova Nataliya V, Dmitriev Alexey A, Krasnov George S, Kudryavtseva Anna V
Abstract excerpt
Carotid paragangliomas (CPGLs) are rare neuroendocrine tumors often associated with mutations in SDHx genes. The immunohistochemistry of succinate dehydrogenase (SDH) subunits has been considered a useful instrument for the prediction of SDHx mutations in paragangliomas/pheochromocytomas. We compared the mutation status of SDHx genes with the immunohistochemical (IHC) staining of SDH subunits in CPGLs. To...
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