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Article

Establishment of a patient-derived orthotopic osteosarcoma mouse model.

Journal of translational medicine - 30 Apr 2015

Blattmann Claudia, Thiemann Markus, Stenzinger Albrecht, Roth Eva K, Dittmar Anne, Witt Hendrik, Lehner Burkhard, Renker Eva, Jugold Manfred, Eichwald Viktoria, Weichert Wilko, Huber Peter E, Kulozik Andreas E

Abstract excerpt

BACKGROUND: Osteosarcoma (OS) is the most common pediatric primary malignant bone tumor. As the prognosis for patients following standard treatment did not improve for almost three decades, functional preclinical models that closely reflect important clinical cancer characteristics are urgently needed to develop and evaluate new treatment strategies. The objective of this study was to establish an orthotopic...

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Source

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Identifiers

PMID: 25926029
DOI: 10.1186/s12967-015-0497-x
PMCID: PMC4428092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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