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Article

Titin-related Cardiomyopathy: Is it a Distinct Disease?

Current cardiology reports - 1 Sept 2022

Santiago Celine F, Huttner Inken G, Fatkin Diane

Abstract excerpt

PURPOSE OF REVIEW: Truncating TTN variants (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM), but the underlying mechanisms are incompletely understood and effective therapeutic strategies are lacking. Here we review recent data that shed new light on the functional consequences of TTNtv and how these effects may vary with mutation location. RECENT FINDINGS: Whether TTNtv act by...

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PMID: 35759169
DOI: 10.1007/s11886-022-01726-0

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