Article
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population.
Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2000
Eskandari Ebrahim, Metanat Malihe, Pahlevani Elham, Nakhzari-Khodakheir Tooba
Abstract excerpt
INTRODUCTION:: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated with CHB infection in...
Topics
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Extracellular Matrix Proteins
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Hepatitis B, Chronic
- Humans
- Iran
- Male
- Middle Aged
- Polymorphism, Genetic
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Young Adult