Article
Association between TGFβ1 polymorphisms and chronic hepatitis B infection in an Iranian population.
Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2000
Eskandari Ebrahim, Metanat Malihe, Pahlevani Elham, Nakhzari-Khodakheir Tooba
Abstract excerpt
INTRODUCTION:: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated with CHB infection in...
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