TNF-α and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals.

doi:10.1002/jmv.24501

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Article

TNF-α and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals.

Journal of medical virology - 1 Sept 2016

Aroucha Dayse Celia, Carmo Rodrigo Feliciano, Vasconcelos Luydson Richardson Silva, Lima Raul Emidio, Mendonça Taciana Furtado, Arnez Lucia Elena, Cavalcanti Maria do Socorro Mendonça, Muniz Maria Tereza Cartaxo, Aroucha Marcilio Lins, Siqueira Erika Rabelo, Pereira Luciano Beltrão, Moura Patrícia, Pereira Leila Maria Moreira Beltrão, Coêlho Maria Rosangela

Abstract excerpt

Hepatitis C virus (HCV) is the major cause of hepatocellular carcinoma (HCC). The risk to develop HCC increases with the severity of liver inflammation and hepatic fibrosis. It is believed that a balance between the releases of pro- and anti-inflammatory cytokines will determine the clinical course of HCV and the risk to develop HCC. The inteleukin-10 (IL-10) and the tumor necrosis factor alpha (TNF-α) play key...

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PMID: 26890368
DOI: 10.1002/jmv.24501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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