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Article

Mutations make gut antibodies promiscuous.

The Journal of experimental medicine - 2 Nov 2020

Grasset Emilie K, Cerutti Andrea

Abstract excerpt

In this issue, Kabbert et al. (https://doi.org/10.1084/jem.20200275) show that intestinal antibodies from healthy subjects or patients with Crohn's disease cross-target diverse but distinct communities of the gut microbiota through a mechanism involving somatic hypermutation but not germline-encoded polyreactivity.

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Identifiers

PMID: 32960963
DOI: 10.1084/jem.20201340
PMCID: PMC7596828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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