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Mechanisms and disease implications of sirtuin-mediated autophagic regulation

1 Sept 2019

Abstract excerpt

Accumulating evidence has indicated that sirtuins are key components of diverse physiological processes, including metabolism and aging. Sirtuins confer protection from a wide array of metabolic and age-related diseases, such as cancer, cardiovascular and neurodegenerative diseases. Recent studies have also suggested that sirtuins regulate autophagy, a protective cellular process for homeostatic maintenance in...

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PMID: 31492861
DOI: 10.1038/s12276-019-0302-7

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