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Risk factors associated with large clusters of tuberculosis patients determined by whole-genome sequencing in a high-tuberculosis-burden country.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2020

Miyahara Reiko, Smittipat Nat, Juthayothin Tada, Yanai Hideki, Disratthakit Areeya, Imsanguan Worarat, Intralawan Daranee, Nedsuwan Supalert, Chaiyasirinroje Boonchai, Bupachat Surasit, Tokunaga Katsushi, Mahasirimongkol Surakameth, Palittapongarnpim Prasit

Abstract excerpt

Whole-genome sequencing (WGS) analysis has great discriminative power for detecting similar molecular fingerprints of suspected tuberculosis (TB) clusters. The proportion of TB cases within clusters and the associated risk factors are important epidemiological parameters guiding appropriate outbreak control strategies in endemic settings. We conducted a hospital-based TB case-cohort study between 2003 and 2011 in...

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PMID: 32949880
DOI: 10.1016/j.tube.2020.101991

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