Article
A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis.
International journal of molecular medicine - 1 Oct 2020
Butzmann Alexandra, Sridhar Kaushik, Jangam Diwash, Kumar Jyoti, Sahoo Malaya Kumar, Shahmarvand Nahid, Warnke Roger, Rangasamy Elumalai, Pinsky Benjamin Alan, Ohgami Robert Shigeo
Abstract excerpt
Angioimmunoblastic T‑cell lymphoma (AITL) is a uniquely aggressive mature T‑cell neoplasm. In recent years, recurrent genetic mutations in ras homolog family member A (RHOA), tet methylcytosine dioxygenase 2 (TET2), DNA methyltransferase 3 alpha (DNMT3A) and isocitrate dehydrogenase [NADP(+)] 2 (IDH2) have been identified as associated with AITL. However, a deep molecular study assessing both DNA mutations and...
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