Article
2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments.
European journal of medicinal chemistry - 15 Dec 2020
El-Damasy Ashraf K, Haque Md Mamunul, Park Jung Woo, Shin Sang Chul, Lee Jun-Seok, EunKyeong Kim Eunice, Keum Gyochang
Abstract excerpt
Prompted by the urgent demand for identification of new anticancer agents with improved potency and efficacy, a new series of arylamides incorporating the privileged 2-anilinoquinoline scaffold has been designed, synthesized, and biologically assessed. Aiming at extensive evaluation of the target compounds' potency and spectrum, a panel of 60 clinically important cancer cell lines representing nine cancer types...
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