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Article

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors.

International journal of molecular sciences - 27 Aug 2023

El-Sheref Essmat M, Bräse Stefan, Tawfeek Hendawy N, Alasmary Fatmah Ali, Youssif Bahaa G M

Abstract excerpt

The reaction of 4-azido-quinolin-2(1H)-ones 1a-e with the active methylene compounds pentane-2,4-dione (2a), 1,3-diphenylpropane-1,3-dione (2b), and K2CO3 was investigated in this study. This approach afforded 4-(1,2,3-triazol-1-yl)quinolin-2(1H)-ones 3a-j in high yields and purity. All newly synthesized products' structures were identified. Compounds 3a-j were tested for antiproliferative activity against a...

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PMID: 37686105
DOI: 10.3390/ijms241713300
PMCID: PMC10488242

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