Article
Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma.
Gut - 1 Oct 2021
Grant Robert C, Denroche Robert, Jang Gun Ho, Nowak Klaudia M, Zhang Amy, Borgida Ayelet, Holter Spring, Topham James T, Wilson Julie, Dodd Anna, Jang Raymond, Prince Rebecca, Karasinska Joanna M, Schaeffer David F, Wang Yifan, Zogopoulos George, Berry Scott, Simeone Diane, Renouf Daniel J, Notta Faiyaz, O'Kane Grainne, Knox Jennifer, Fischer Sandra, Gallinger Steven
Abstract excerpt
OBJECTIVE: To describe the clinical, pathological and genomic characteristics of pancreatic cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP). DESIGN: We identified patients with MMRD and MMRP pancreatic cancer in a clinical cohort (N=1213, 519 with genetic testing, 53 with immunohistochemistry (IHC)) and a genomic cohort (N=288 with whole-genome sequencing (WGS)). RESULTS: 12 out of 1213...
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