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Article

The pancreatic cancer genome revisited.

Nature reviews. Gastroenterology & hepatology - 1 Jul 2021

Hayashi Akimasa, Hong Jungeui, Iacobuzio-Donahue Christine A

Abstract excerpt

Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of pancreatic cancer indicate the cellular processes that are targeted for malignant transformation. In addition to somatic alterations in the most common driver genes (KRAS, CDKN2A, TP53 and SMAD4), large-scale studies have revealed major roles for genetic alterations of the SWI/SNF and COMPASS complexes, copy number...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34089011
DOI: 10.1038/s41575-021-00463-z

Genes

KRAS
CDKN2A
GATA6
MYC
NRG1
NTRK1
SMAD4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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