Article
Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2018
Hu Zishuo I, Shia Jinru, Stadler Zsofia K, Varghese Anna M, Capanu Marinela, Salo-Mullen Erin, Lowery Maeve A, Diaz Luis A, Mandelker Diana, Yu Kenneth H, Zervoudakis Alice, Kelsen David P, Iacobuzio-Donahue Christine A, Klimstra David S, Saltz Leonard B, Sahin Ibrahim H, O'Reilly Eileen M
Abstract excerpt
Purpose: Immune checkpoint inhibition has been shown to generate profound and durable responses in mismatch repair deficient (MMR-D) solid tumors and has elicited interest in detection tools and strategies to guide therapeutic decision-making. Herein we address questions on the appropriate screening, detection methods, patient selection, and initiation of therapy for MMR-D pancreatic ductal adenocarcinoma (PDAC)...
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