Article
Huntingtin protein maintains balanced energetics in mouse cardiomyocytes.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2022
Tomczyk Marta, Glaser Talita, Ulrich Henning, Slominska Ewa M, Smolenski Ryszard T
Abstract excerpt
Huntingtin (HTT) is a multifunctional protein crucial for proper embryogenesis and nervous system development. Mutation of a single allele in gene coded this protein results in the Huntington׳s disease (HD). There is growing evidence of cardiovascular system pathologies coexisting with the neurological symptoms in HD patients. Thus, this study aims to establish the role of huntingtin protein in cardiomyocytes...
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