Sensitivity of polyamine-deficient Saccharomyces cerevisiae to elevated temperatures.

Abstract excerpt

Saccharomyces cerevisiae cells that cannot synthesize spermidine or spermine because of a deletion in the gene coding for S-adenosylmethionine decarboxylase are very sensitive to elevated temperatures when incubated in a polyamine-deficient medium; i.e., growth is inhibited and the cells are killed. This sensitivity is very pronounced at 39 degrees C, but a moderate effect is noted even at 33 to 34 degrees C....

Topics

• Adenosylmethionine Decarboxylase
• Hot Temperature
• Mutation
• Polyamines
• Saccharomyces cerevisiae
• Spermidine