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Article

Genetic alterations leading to increases in internal potassium concentrations are detrimental for DNA integrity in Saccharomyces cerevisiae.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2011

Merchan Stephanie, Pedelini Leda, Hueso Guillem, Calzada Arturo, Serrano Ramón, Yenush Lynne

Abstract excerpt

We have investigated the effects of alterations in potassium homeostasis on cell cycle progression and genome stability in Saccharomyces cerevisiae. Yeast strains lacking the PPZ1 and PPZ2 phosphatase genes, which aberrantly accumulate potassium, are sensitive to agents causing replicative stress or DNA damage and present a cell cycle delay in the G(1) /S phase. A synthetic slow growth phenotype was identified in...

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Identifiers

PMID: 21143561
DOI: 10.1111/j.1365-2443.2010.01472.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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