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Article

MasterPATH: network analysis of functional genomics screening data.

BMC genomics - 14 Sept 2020

Rubanova Natalia, Pinna Guillaume, Kropp Jeremie, Campalans Anna, Radicella Juan Pablo, Polesskaya Anna, Harel-Bellan Annick, Morozova Nadya

Abstract excerpt

BACKGROUND: Functional genomics employs several experimental approaches to investigate gene functions. High-throughput techniques, such as loss-of-function screening and transcriptome profiling, allow to identify lists of genes potentially involved in biological processes of interest (so called hit list). Several computational methods exist to analyze and interpret such lists, the most widespread of which aim...

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PMID: 32928103
DOI: 10.1186/s12864-020-07047-2
PMCID: PMC7491077

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