Article
Lung immunoglobulin A immunity dysregulation in cystic fibrosis.
EBioMedicine - 1 Oct 2020
Collin Amandine M, Lecocq Marylène, Noel Sabrina, Detry Bruno, Carlier François M, Aboubakar Nana Frank, Bouzin Caroline, Leal Teresinha, Vermeersch Marjorie, De Rose Virginia, Regard Lucile, Martin Clémence, Burgel Pierre-Régis, Hoton Delphine, Verleden Stijn, Froidure Antoine, Pilette Charles, Gohy Sophie
Abstract excerpt
BACKGROUND: In cystic fibrosis (CF), recurrent infections suggest impaired mucosal immunity but whether production of secretory immunoglobulin A (S-IgA) is impaired remains elusive. S-IgA is generated following polymeric immunoglobulin receptor (pIgR)-mediated transepithelial transport of dimeric (d-)IgA and represents a major defence through neutralisation of inhaled pathogens like Pseudomonas aeruginosa (Pa)....
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