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Article

Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer.

Oncoimmunology - 30 Jun 2020

Chen Hao, Chong Wei, Yang Xiaorong, Zhang Yuan, Sang Shaowei, Li Xiangchun, Lu Ming

Abstract excerpt

Triple-negative breast cancer (TNBC) is characterized by broad genomic and transcriptional heterogeneity and results in a worse prognosis than other breast cancer types. Here, we integrated genomic and transcriptomic data combined with clinicopathologic information from 538 patients with TNBC and identified four novel significantly mutated genes (SMGs), namely, KDM6A, CD86, RBM47, and IFNGR1. A mutational...

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Identifiers

PMID: 32923150
DOI: 10.1080/2162402X.2020.1788252
PMCID: PMC7458648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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