The Experiences and Needs of Individuals with a Variant of Uncertain Significance on Genetic Tests for Hereditary Cancer Syndromes:A Grounded Theory Study.

doi:10.1016/j.soncn.2026.152148

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Article

The Experiences and Needs of Individuals with a Variant of Uncertain Significance on Genetic Tests for Hereditary Cancer Syndromes:A Grounded Theory Study.

Seminars in oncology nursing - 1 Apr 2026

Gould Danielle, Walker Rae, Makari-Judson Grace, Seven Memnun

Abstract excerpt

OBJECTIVES: The use of multigene panel testing to identify hereditary cancer susceptibility has led to a growing number of individuals receiving a variant of uncertain significance (VUS) result. This qualitative study aimed to describe the experiences of individuals with a VUS, with a focus on their communication with healthcare providers (HCPs) and family members. METHODS: This study employed a constructivist...

Topics

Humans
Grounded Theory
Female
Genetic Testing
Male
Middle Aged
Adult
Uncertainty
Neoplastic Syndromes, Hereditary
Qualitative Research
Genetic Predisposition to Disease
Aged
Decision Making

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Open in PubMed

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PMID: 41720719
DOI: 10.1016/j.soncn.2026.152148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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