Article
Genome-wide association study identifies novel single nucleotide polymorphisms having age-specific effect on prostate-specific antigen levels.
The Prostate - 1 Dec 2020
Li Weiqiang, Bicak Mesude, Sjoberg Daniel D, Vertosick Emily, Dahlin Anders, Melander Olle, Ulmert David, Lilja Hans, Klein Robert J
Abstract excerpt
BACKGROUND: Testing for prostate-specific antigen (PSA) levels in blood are widely used and associated with prostate cancer risk and outcome. After puberty, PSA levels increase by age and multiple single nucleotide polymorphisms (SNPs) have been found to be associated with PSA levels. However, the relationship between the effects of SNPs and age on PSA remains unknown. METHODS: To test for SNP × age interaction,...
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