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Functional haplotype in the Interleukin8 (CXCL8) gene is associated with type 2 Diabetes Mellitus and Periodontitis in Brazilian population.

Diabetes & metabolic syndrome - 1 Jan 2000

Silva Bárbara Roque da, Cirelli Thamiris, Nepomuceno Rafael, Theodoro Letícia Helena, Orrico Silvana R P, Cirelli Joni A, Barros Silvana P, Scarel-Caminaga Raquel M

Abstract excerpt

BACKGROUND AND AIM: Type 2 Diabetes Mellitus (T2DM) and Periodontitis (P) are prevalent multifactorial disorders worldwide, sharing a bidirectional relationship influenced by the genetic susceptibility of the host immune system. We investigated whether SNPs in the Interleukin 8 (IL8, alias CXCL8) gene could be associated with T2DM and Periodontitis. METHODS: Genomic DNA was obtained from 874 Brazilian individuals...

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PMID: 32905938
DOI: 10.1016/j.dsx.2020.08.036

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