Identification of Inner Mucus-Associated Bacteria by Laser Capture Microdissection

Abstract excerpt

A primary means by which the intestine is protected against microbial onslaught is by production of a thick mucus gel that serves to physically separate the microbiota from epithelial cells. Accordingly, the outer regions of the mucus layer are heavily colonized by bacteria while the inner layer is nearly sterile.1 Alterations in intestinal microbiota composition are associated with various disease states,...

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