Article
A commonly carried genetic variant, rs9616915, in SHANK3 gene is associated with a reduced risk of autism spectrum disorder: replication in a Chinese population.
Molecular biology reports - 1 Mar 2014
Shao Shanshan, Xu Sanqing, Yang Jun, Zhang Ti, He Zhen, Sun Zhao, Song Ranran
Abstract excerpt
Autism spectrum disorder (ASD) is one of neurodevelopmental disorders with highly heritability. Recently, abnormality at the synapse is found to be important etiology of ASD. SHANK3 gene is suggested as a strong candidate gene for the pathogenesis of ASD, because it is essential for normally synaptic structure and function. We performed a case-control study to identify association between rs9616915 of the SHANK3...
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