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Article

Mitogen-activated protein kinase p38 modulates pacemaker ion channels differentiation in P19-derived pluripotent cells.

The journal of physiological sciences : JPS - 7 Sept 2020

Zheng Mingqi, Kang Lin, Uchino Tomoko, Liu Gang, Wang Yan, Ono Katsushige

Abstract excerpt

Signal regulators during early cardiogenetic differentiation for the cellular automaticity are largely unknown. Our investigations were designed to clarify the role of transcription factors and their modulators in P19-derived cardiomyocytes to the expression of cardiac pacemaker ion channels. Transcription factors Csx/Nkx2.5 and GATA4 but not MEF2C were markedly inhibited by p38 MAP kinase inhibition in a...

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Identifiers

PMID: 32895058
DOI: 10.1186/s12576-020-00766-x
PMCID: PMC10717480

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