Article
Association of Interleukin 10 (IL-10) Gene with Type 2 Diabetes Mellitus by Single Nucleotide Polymorphism of Its Promotor Region G/A 1082.
Critical reviews in eukaryotic gene expression - 1 Jan 2020
Naz Shagufta, Shafique Nida, Sharif Saima, Manzoor Farkhanda, Saifi Sher Zaman, Firasat Sabika, Kaul Haiba
Abstract excerpt
Interleukin 10 (IL-10) is an anti-inflammatory cytokine with lower circulating levels in patients with type 2 diabetes mellitus (T2DM). Cytokines such as IL-10 downregulate the production of pro-inflammatory cytokines, which impair proper function of insulin. So any mutation in the IL-10 gene results in increased production of proinflammatory cytokines, which in turn affect insulin action and cause T2DM. In this...
Topics
- Diabetes Mellitus, Type 2
- Down-Regulation
- Humans
- Inflammation Mediators
- Interleukin-10
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic