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Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

7 Sept 2020

Abstract excerpt

BACKGROUND: Viral load is a major contributor to outcome in patients with Ebola virus disease (EVD), with high values leading to a fatal outcome. Evidence from the 2013-2016 Ebola virus (EBOV) outbreak indicated that different genotypes of the virus can have different phenotypes in patients. Additionally, due to the error-prone nature of viral RNA synthesis in an individual patient, the EBOV genome exists around...

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PMID: 32894206
DOI: 10.1186/s13059-020-02148-3

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