The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm.

Abstract excerpt

Abdominal aortic aneurysm (AAA) is characterised by the chronic degradation and gradual, irreversible dilation of the abdominal aorta. Smoking, genetics, male sex and increased age are major factors associated with developing AAA. Rupture contributes to around 2% of deaths in all Caucasians over 65, and there is no pharmaco-therapeutic treatment. Methylation is an epigenetic modification to DNA, where a methyl...

Topics

Join the communities discussing this publication.

• Aging
• Aorta, Abdominal
• Aortic Aneurysm, Abdominal
• CpG Islands
• Dilatation, Pathologic