Article
Genetic and epigenetic mechanisms and their possible role in abdominal aortic aneurysm.
Atherosclerosis - 1 Sept 2010
Krishna Smriti M, Dear Anthony E, Norman Paul E, Golledge Jonathan
Abstract excerpt
Abdominal aortic aneurysm (AAA) is a common disease associated with significant cardiovascular morbidity and mortality. The pathogenesis of AAA is poorly defined, making targeting of new therapies problematic. Current evidence favours an interaction of multiple environmental and genetic factors in the initiation and progression of AAA. Epigenetics is the term used to define the properties of the genome that are...
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