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Article

miR760 regulates ATXN1 levels via interaction with its 5' untranslated region.

Genes & development - 1 Sept 2020

Nitschke Larissa, Tewari Ambika, Coffin Stephanie L, Xhako Eder, Pang Kaifang, Gennarino Vincenzo A, Johnson Jennifer L, Blanco Francisco A, Liu Zhandong, Zoghbi Huda Y

Abstract excerpt

Identifying modifiers of dosage-sensitive genes involved in neurodegenerative disorders is imperative to discover novel genetic risk factors and potential therapeutic entry points. In this study, we focus on Ataxin-1 (ATXN1), a dosage-sensitive gene involved in the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1). While the precise maintenance of ATXN1 levels is essential to prevent disease, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32763910
DOI: 10.1101/gad.339317.120
PMCID: PMC7462065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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